Film | Rôle | Année |
|---|
| Social! Distance Dance Club | | 2021 |
| Stop Making Sense | Self - Vocals, Guitar | 1984 |
| True Stories | Narrator / Lip-Syncher | 1986 |
| Talking Heads: Rock Pop in Concert | | 1981 |
| Heavy Petting | Self | 1989 |
| Elvis Costello and Burt Bacharach: Sessions at West 54th | Self - Host/Interviewer | 1998 |
| Fathers and Songs: Music for Father's Day | Self (archive footage) | 2013 |
| Hollywood Rocks the Movies: The 1970s | Self | 2002 |
| Paul Simon: Under African Skies | Self | 2012 |
| Dead End Kids | Minister | 1986 |
| Twyla Moves | Self | 2021 |
| This Must Be the Place | David Byrne | 2011 |
| The Kitchen Presents: Two Moon July | | 1986 |
| Lou Reed: Rock and Roll Heart | Self | 1998 |
| Talking Heads: Live at Montreux Jazz Festival | | 1982 |
| Lulu on the Bridge | "Laughing Man" Escort | 1998 |
| Between the Teeth | | 1993 |
| Talking Heads: Storytelling Giant | Self | 1988 |
| The Making of True Stories | Self | 2018 |
| O Homem Que Engarrafava Nuvens | Self | 2008 |
| Ride, Rise, Roar | Self | 2011 |
| Talking Heads: The Name of this Programme is Once In A Lifetime | Self | 1984 |
| Fabricando Tom Zé | Self | 2006 |
| Beyond Ipanema | Self | 2009 |
| Café Tacvba - Un Segundo / MTV Unplugged | Self - Voice | 2019 |
| Celia: The Queen | Self | 2008 |
| Tori Amos: Sessions at West 54th | Self | 1998 |
| The Pogues Live at the Town and Country | Self | 2004 |
| Talking Heads - Chronology | | 2011 |
| Michael Jackson - Naissance d'une légende | Self | 2016 |
| Lennon or McCartney | Self | 2014 |
| David Byrne - Live from Austin, Texas | Self - Vocals, guitar | 2007 |
| Contemporary Color | | 2016 |
| The Blank Generation | Self | 1976 |
| Talking Heads in concerto | Self - Vocals, guitar | 1980 |
| Talking Heads: Capitol Theatre | Self - Lead Vocals, Guitar | 1980 |
| TV Party | Self | 2005 |
| Coração Vagabundo | Self | 2009 |
| 10000 Maniacs: MTV Unplugged | Self | 1993 |
| 25 Years of Punk | Self | 2001 |
| We're Gonna Die | David Byrne | 2015 |
| Museum Town | Self | 2019 |
| Burning Down the House: The Story of CBGB | Self | 2009 |
| John Mulaney et les kids | David Byrne | 2019 |
| Lubbock Lights | Self | 2003 |
| Dancing Barefoot | Self | 1995 |
| Well How Did We Get Here? A Brief History of Talking Heads | Self | 2017 |
| Everything For All Reasons | Self | 2019 |
| Decade | Self | 1989 |
| David Byrne's American Utopia | Self - Lead Singer & Performer | 2020 |
| Checking Out | Bartender | 1988 |
| By the Ways, a Journey with William Eggleston | Self | 2006 |
| David Byrne: ACL Fest 2018 | Self | 2018 |
| Red Hot + Blue: A Tribute to Cole Porter | Self | 1990 |
| A Arte de Amália | Introduction (English version) | 2000 |
| La Casa del Ritmo: A Film About Los Amigos Invisibles | | 2012 |
| Фили. История одного лейбла | Self | 2020 |
| Hream | David Byrne | 2019 |
| David Byrne: Live At Union Chapel | | 2003 |
| Temporary Color | | 2016 |
| Triple-Chaser | Narrator | 2019 |
| NY77: The Coolest Year in Hell | Self (archive footage) (uncredited) | 2007 |
| Wild Combination: A Portrait of Arthur Russell | Self (archive footage) | 2008 |
| New York Rock at the BBC | | 2008 |
| Beleza Tropical | Self | 1990 |
| Tom Zé: Astronauta Libertado | | 2009 |
| Dennis Cleveland | | 2004 |
| Homo Brasilis: Tom Zé, o Tropicalista Visionário | Self (archive footage) | 2023 |
| SNL50: The Homecoming Concert | Self | 2025 |
| Ladies & Gentlemen... 50 Years of SNL Music | Self | 2025 |
| Report From L.A. | Himself | 1986 |
| Real Life | Narrator / Self | 2018 |
| Monk in Pieces : Meredith Monk, l'instinct de la voix | Self | 2025 |
| We Want the Funk ! | Self | 2025 |
| Untitled Patton/Byrne Piece | | 2008 |
| PJ Harvey: Sessions at West 54th | | 1998 |
| Les Deux Gredins | Gordon Sniffles (voice) | 2025 |
| Changing Lanes | Self | 2026 |
| Stranger: Bernie Worrell on Earth | Self | 2005 |
| David Byrne - Live From Teatro Gran Rex | Self | 1998 |
| Talking Heads: 77 | | |
| Jusqu'au bout du monde | Self | 1991 |
| Eno | Self | 2024 |
| Point de rupture : 1975 | (archive footage) | 2025 |
| David Byrne: Who Is The Sky? | Self | |
| Miley's New Year's Eve Party | Self | 2022 |
| Robert Wilson and the Civil Wars | | 2026 |
| Each Day in a Moment: 2025 | Self (archive footage) (uncredited) | 2026 |
