Film | Rôle | Année |
|---|
| Duo à trois | Annie Savoy | 1988 |
| Spéciale première | Peggy Grant | 1974 |
| Thelma & Louise | Louise | 1991 |
| The Haunting of Rosalind | Dita | 1973 |
| La Dernière Marche | Sister Helen Prejean | 1995 |
| James et la Pêche géante | Miss Spider (voice) | 1996 |
| Bob Roberts | Tawna Titan | 1992 |
| Lorenzo | Michaela Odone | 1992 |
| The Player | Susan Sarandon | 1992 |
| Le Client | Reggie Love | 1994 |
| Shall We Dance ? La Nouvelle Vie de monsieur Clark | Beverly Clark | 2004 |
| Il était une fois | Queen Narissa | 2007 |
| Le Roi des gitans | Rose | 1978 |
| Ma mère, moi et ma mère | Adele August | 1999 |
| Moonlight Mile | Jojo Floss | 2002 |
| Les Sorcières d'Eastwick | Jane Spofford | 1987 |
| Atlantic City | Sally | 1980 |
| Speed Racer | Mom Racer | 2008 |
| Le Secret de Peacock | Fanny Crill | 2010 |
| Lovely Bones | Grandma Lynn | 2009 |
| Dans la vallée d'Elah | Joan Deerfield | 2007 |
| Les Prédateurs | Sarah Roberts | 1983 |
| Calendrier meurtrier | Christine Starkey | 1989 |
| Une saison blanche et sèche | Melanie Bruwer | 1989 |
| Irrésistible Alfie | Liz | 2004 |
| Pour l'amour de Bennett | Grace Brewer | 2009 |
| L'Heure magique | Catherine Ames | 1998 |
| Ma meilleure ennemie | Jackie Harrison | 1998 |
| Sex Fans des Sixties | Lavinia | 2002 |
| La Petite | Hattie | 1978 |
| Escroc(s) en herbe | Daisy Kincaid | 2009 |
| Les Quatre Filles du docteur March | Mrs. March | 1994 |
| Rencontres à Elizabethtown | Hollie Baylor | 2005 |
| Monsieur Woodcock | Beverly Farley | 2007 |
| Igby | Mimi | 2002 |
| Emotional Arithmetic | Melanie Lansing Winters | 2008 |
| Wall Street : L'argent ne dort jamais | Sylvia Moore | 2010 |
| La Fièvre d'aimer | Nora Baker | 1990 |
| Noël | Rose Collins | 2004 |
| Romance & Cigarettes | Kitty Kane | 2005 |
| La Dernière Route | Ginny | 1978 |
| Light Sleeper | Ann | 1992 |
| The Rocky Horror Picture Show | Janet Weiss | 1975 |
| Solitary Man | Nancy Kalmen | 2009 |
| La Vérité sur Jack | Janet Good | 2010 |
| Arbitrage | Ellen Miller | 2012 |
| Copain, copine | Emily | 1984 |
| Fight for Your Right Revisited | Mother | 2011 |
| Bernard and Doris | Doris Duke | 2006 |
| The Nazi Officer's Wife | Narrator (voice) | 2003 |
| Les Razmoket à Paris, le film | Coco LaBouche (voice) | 2000 |
| Joe | Melissa Compton | 1970 |
| Tempête | Aretha Tomalin | 1982 |
| Irresistible | Sophie Hartley | 2006 |
| Loin des yeux, près du cœur | Mag | 1994 |
| Sweet Hearts Dance | Sandra "Sandy" Boon | 1988 |
| De l'autre côté de minuit | Catherine Alexander Douglas | 1977 |
| Middle of Nowhere | Rhonda Berry | 2008 |
| La Kermesse des Aigles | Mary Beth | 1975 |
| La prison de glace | Dr. Jerri Nielsen | 2003 |
| Jeff, Who Lives at Home | Sharon Thompkins | 2012 |
| Cloud Atlas | Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess | 2012 |
| Illuminata | Celimene | 1998 |
| Robot & Frank | Jennifer | 2012 |
| Healing US | Narrator | 2023 |
| Wilderness: The Last Stand | Self - Narrator (voice) | 1993 |
| Crazy Dad | Mary McGarricle (Present Day) | 2012 |
| Sous surveillance | Sharon Solarz | 2012 |
| Un grand mariage | Beatrice 'Bebe' McBride | 2013 |
| Fleur Bleue | Elizabeth Hawkins | 1971 |
| Something Short of Paradise | Madeline Ross | 1979 |
| This Is What Democracy Looks Like | Narrator (voice) | 2000 |
| Rocky Horror 45: The Movie | Self | 2021 |
| Ghosts of Attica | Narrator | 2001 |
| Joe Gould's Secret | Alice Neel | 2000 |
| How to Make Money Selling Drugs | Self | 2012 |
| Compromising Positions | Judith Singer | 1985 |
| Nothing Like Chocolate | Narrator (voice) | 2012 |
| Rudyland | Narrator (voice) | 2001 |
| Checkered Flag or Crash | C.C. Wainwright | 1977 |
| Nonnas | Gia | 2025 |
| The Peace! | Self | 2005 |
| Mortadella | Sally | 1971 |
| Infiltré | Joanne Keeghan | 2013 |
| Who Am I This Time? | Helene Shaw | 1982 |
| Blue Beetle | Victoria Kord | 2023 |
| Forty Winks | Connie Montoya | 2022 |
| Lovin' Molly | Sarah | 1974 |
| Oui, je le veux ? | Monica | 2023 |
| Dragonfly | Chloe | 1976 |
| Bataan, le camp de l'enfer | Col. Margaret Ann Jessup | 1986 |
| The Last of Robin Hood | Florence Aadland | 2013 |
| The Fabulous Four | Lou | 2024 |
| The Rimers of Eldritch | Patsy Johnson | 1972 |
| Tammy | Pearl | 2014 |
| School of Assassins | Narrator (voice) | 1994 |
| Loving Couples | Stephanie | 1980 |
| Ping Pong Summer | Randi Jammer | 2014 |
| The Exonerated | Sunny Jacobs | 2006 |
| Hollywood contra Franco | Self - Actress | 2009 |
| The Shaman's Apprentice | Narrator (voice) | 2001 |
| Islamic Art: Mirror of the Invisible World | Narrator (voice) | 2011 |
| Les fugueurs | Charlotte Emory | 1999 |
| The Calling | Hazel Micallef | 2014 |
| Grizzly | Narrator (voice) | 2009 |
| Gracie & Pedro: Pets to the Rescue | Shades (voice) | 2024 |
| Stardust: The Bette Davis Story | Narrator (voice) | 2006 |
| Irwin & Fran | Narrator | 2013 |
| Byron Bowers: Spiritual N***a | Self (uncredited) | 2022 |
| Super/Man: L'histoire de Christopher Reeve | Self | 2024 |
| Thelma & Louise: The Last Journey | Self | 2003 |
| Ma mère et moi | Marnie Minervini | 2016 |
| Hell and Back | Barb the Angel (voice) | 2015 |
| Secrets of the Code | Narrator (voice) | 2006 |
| About Ray | Dolly | 2016 |
| Unity | Narrator (voice) | 2015 |
| Behind the Music: The Rocky Horror Picture Show | Self | 1999 |
| The Gutter | Linda Curson | 2024 |
| Spark : L'héritier de la planète des singes | Bananny (voice) | 2016 |
| Messagères de guerre | Eleanor Roosevelt | 2024 |
| Rebel Nun | | 2024 |
| Broadway, 39ème rue | Margherita Sarfatti | 1999 |
| The Next Industrial Revolution | Narrator (voice) | 2002 |
| Mothers and Daughters | Millie | 2016 |
| Exit Right | Jan Randall | |
| 12-12-12 The Concert for Sandy Relief | Self | 2012 |
| Our Friend, Martin | Mrs. Clark (voice) | 1999 |
| Zoolander 2 | Susan Sarandon (uncredited) | 2016 |
| Ma vie avec John F. Donovan | Grace Donovan | 2019 |
| Materia Viva | Self | 2024 |
| Ace the Case: Manhattan Mystery | Detective Dottie Wheel | 2016 |
| My Entire High School Sinking Into the Sea | Lunch Lady Lorraine (voice) | 2016 |
| F. Scott Fitzgerald and the Last of the Belles | Ailie Calhoun | 1974 |
| Comme chiens et chats | Ivy (voice) | 2001 |
| The Jesus Rolls | Jean | 2019 |
| Moonlight Mile: A Journey to Screen | Self / Jojo Floss | 2003 |
| Beauty and the Beast | Beauty | 1984 |
| The Past Is a Grotesque Animal | Self | 2014 |
| One Woman, One Vote | Narrator (voice) | 1995 |
| Butterfly in the Typewriter | Thelma Toole | |
| The Celluloid Closet | Self | 1996 |
| Bad Moms 2 | Isis Dunkler | 2017 |
| Survivor's Guide to Prison | Narrator (voice) | 2018 |
| Ljuset håller mig sällskap | Self | 2000 |
| Night of Too Many Stars: America Unites for Autism Programs | Self | 2017 |
| We Are Many | Self | 2014 |
| Viper Club | Helen | 2018 |
| Bull Durham: Between the Lines | Self | 2002 |
| Trailblazers in Habits | Narrator (voice) | 2013 |
| The Secret Life of Geisha | Narrator (voice) | 1999 |
| The Concert for New York City | Self | 2001 |
| Blackbird | Lily | 2019 |
| Pip's Predicament: A Pop-Up Adventure | Queen Narissa (voice) | 2008 |
| The Satan Murders | Kate | 1974 |
| Father Roy: Inside the School of Assassins | Narrator (voice) | 1996 |
| The Education of Gore Vidal | Self | 2003 |
| Facing Arthur | Narrator (voice) | 2002 |
| The Rocky Horror Double Feature Video Show | Self | 1995 |
| VHYes | Tracy Beth | 2020 |
| Tunnels | | |
| Home | | 2006 |
| Greenwich Village: Music That Defined a Generation | Suze Rotolo (voice) | 2013 |
| Christa McAuliffe: Reach for the Stars | Narrator (voice) | 2006 |
| LOVE | The Art Teacher | 2020 |
| June Moon | Eileen | 1974 |
| Bad Moms' Moms | Isis | |
| Enzian: When the Lights Go Up | Self (archive footage) | 2015 |
| Pitchfork | | |
| Qui a peur des monstres ? | Mom (voice) | 2020 |
| Still of Night | | |
| Red Bird Lane | | |
| Goodnight Moon & Other Sleepytime Tales | Narrator (voice) | 1999 |
| Behind the Labels | Narrator (voice) | |
| Ride the Eagle | Honey | 2021 |
| Jolt | Woman with No Name | 2021 |
| Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Bitsy | 1994 |
| Jiminy Glick in Lalawood | Susan Sarandon | 2005 |
| PoliWood | Self | 2009 |
| Dirty Pictures | Self | 2000 |
| Rabbit Ears - The Firebird | Narrator (voice) | 1991 |
| Saving Jamaica Bay | Narrator | |
| Last Party 2000 | Self | 2001 |
| Legacy | Warden Stroud | |
| American Mirror - Intimations of Immortality | Muse | 2018 |
| A Question of Habit | Narrator | 2011 |
| Strange Journey: The Story of Rocky Horror | Self | 2025 |
| Broken Child | Self - Narrator (voice) | 2000 |
| Thelma et Louise, un western féministe | Self | 2025 |
| Jack Nicholson: The Joker Is Wild | Self | 2004 |
| The Accompanist | Sylvia | |
| Artistry/Technology | Self | 2015 |
| 100 Greatest Sexy Moments | Self | 2003 |
| The Trust Fall: Julian Assange | Self - Narrator | 2024 |
| VH1: Divas Live | Self - Host | 1998 |
| Baristas vs Billionaires | Narrator | 2025 |
| The Echo Chamber | | |
| Unmerciful Good Fortune | Dr. Irene Charles | |
| Saturday Night Live in the '90s: Pop Culture Nation | Self | 2007 |
| The Shape of Water | Narrator | 2006 |
| What is an Ocean… Reconnecting the Cast and Crew of Cloud Atlas | Self - Interviewee | 2025 |
| Speed Racer: Wonderful World of Racing - The Amazing Racer Family | Mom Racer | 2008 |
