Casting | Rôle |
|---|
| Eben Britton | Self - Former NFL Player (as Eben) |
| Dr. Wendy Brown | Self - Political Theorist, UC Berkeley |
| Ariana | Self - College Sophomore |
| Delaney | Self - College Junior |
| Jasper Holt-Teza | Self - College Senior (as Jasper) |
| Leigh | Self - College Senior |
| Anjan Chatterjee | Self - Chair of Neurology, University of Pennsylvania |
| Alan Schwarz | Self - Journalist, Author - ADHD Nation |
| Nicholas Rasmussen | Self - Author, On Speed |
| Nathanael | Self - Software Engineer |
| Sheila Britt | Self - Eben's Wife (as Brit) |
| Martha Farah | Self - Cognitive Neuroscientist, University of Pennsylvania |
| Carl Hart | Self - Chair of Psychology, Columbia University |
| Lawrence Diller | Self - Pediatrician, Author - Running on Ritalin |
| Steve Hinshaw | Self - Psychologist, Author - The ADHD Explosion |
| Blue Williams | Self - Artist Management (as Blue) |
| Bianka | Self - Leigh's Roommate |
| Liz Jorgensen | Self - Psychotherapist |
| Peter | Self - Financial Analyst |
| Regina Holt-Teza | Self - Jasper's Mom (as Regina) |
| Bill Holt | Self - Jasper's Dad (as Bill) |
| Maxine | Self - Blue's Mom |
| Keith Conner | Self - Conducted First Controlled Ritalin Study |
| Corey Hebert | Self - Pediatrician |
| Rahiem | Self - High School Student |
| Sherry | Self - Rahiem's Mom |
| Jesse Lawler | Self - Podcast Host, Smart Drug Smarts |
| Lucas Siegel | Self - Co-Founder, AlternaScript (as Lucas) |
| Matthew Piskorz | Self - Co-Founder, AlternaScript (as Matthew) |
| Lily | Self - Startup Publicist |
| Dr. James Fadiman | Self - Psychedelic Researcher |
| Gordon Alles | Self (archive footage) |
| Ringo Starr | Self (archive footage) |
| George Harrison | Self (archive footage) |
| John Lennon | Self (archive footage) |
| Paul McCartney | Self (archive footage) |
| Brigid Berlin | Self (archive footage) |
| William S. Burroughs | Self (archive footage) |
| Allen Ginsberg | Self (archive footage) |
| Albert Hofmann | Self (archive footage) |
| Max Jacobson | Self (archive footage) |
| Jack Kerouac | Self (archive footage) |
| Carla Panganiban | Elementary Student (as Karla Panganiban) |
| Charlie Parker | Self (archive footage) |
| Edie Sedgwick | Self (archive footage) |
| Andy Warhol | Self (archive footage) |
| Frank Zappa | Self (archive footage) |
